离开宜昌后,欧阳修对宜昌的蜡梅仍念念不忘,一次雪后,触景生情,欣然写下“昔官西陵江峡间,野花红紫多斓斑。惟有寒梅旧所识,异乡每见心依然”。
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In order to directly assess DNA strands going through the nanopore, two major problems needed solving. The first was that DNA moved too fast to reliably detect; the second was that individual bases still could not be differentiated, just purines and pyrimidines. In 2005, Bayley (who by then had moved to Oxford) made progress on the first issue, working with scientists at the Scripps Institute to slow the template DNA down by adding short “hairpin” structures that partially blocked off the pore. That year, Bayley co-founded Oxford Nanopore Technologies (ONT) to develop the emerging sequencing method. ONT quickly brought together various technologies, licensing IP from the labs of Bayley, Deamer, Branton, and others.